From: David V. Loewe, Jr on
On Thu, 08 Apr 2010 11:00:37 -0500, "David Loewe, Jr."
<dloewe(a)mindspring.com> wrote:

>On Thu, 25 Mar 2010 09:08:04 -0400, "CardsFan" <me(a)here.com> wrote:
>>"David V. Loewe, Jr" <daveloewe(a)charter.net> wrote
>>> On Fri, 5 Mar 2010 04:17:55 -0800 (PST), Tom <drsoong(a)aol.com> wrote:
>>>>On Mar 5, 12:08 am, Jeanne Douglas <hlwd...(a)NOSPAMpacbell.net> wrote:
>>>>> Tom <drso...(a)aol.com> wrote:

>>>>> > Roy and Ahti have run off most of the knowledgeable and fun posters.
>>>>> > The only ones who are left are you, Earl and me! lol
>>>>>
>>>>> Ahem!
>>>>>
>>>>> > I do enjoy seeing posts from Fred, Karl, DG and Dima. That pretty much
>>>>> > covers roll call!
>>>
>>>>Sorry, Jeanne! I haven't seen anything from you in quite some time and
>>>>thought you had gone the way of The Lance.
>>>>
>>>>It's always a pleasure to hear from you!
>>>>
>>>>Thanks for the slap in the head!
>>>
>>> I hardly ever see anyone post anything here worth discussing.
>>
>>I'm glad to see you're still around.
>
>Unfortunately, due to the actions of certain posters driving out most
>normal conversation, I only look in here sporadically (as you can tell
>from the delay in answering your inquiry).
>
>>How's the health stuff going?
>
>Where to begin?
>
>As you may remember, I have inoperable metastatic neuroendocrine
>pancreatic tumors in my liver [1]. I got into a clinical trial here at
>the Siteman Cancer Center in the Center For Advanced Medicine at
>Barnes-Jewish Hospital in town. I was put on the drug Sutent [2], a
>renal cancer drug that has some promise in the treatment of other
>tumors. The drug worked rather well for a while, but has begun to lose
>effectiveness. I am currently on what promises to be my last round or
>cycle of Sutent (as the effectiveness should decrease to the point where
>I am no longer eligible for the study on the next scan) which will end
>May 12th. After that, I'm looking at three primary options -
>
>1) Percutaneous hepatic perfusion
>http://en.wikipedia.org/wiki/Percutaneous_hepatic_perfusion which is
>being run as a Phase II Clinical Trial at NHI in Bethesda MD.
>http://en.wikipedia.org/wiki/Delcath_Systems,_Inc.
>http://en.wikipedia.org/wiki/National_Institutes_of_Health
>http://en.wikipedia.org/wiki/National_Cancer_Institute
>http://www.msnbc.msn.com/id/29960694
>I still need an MRI of my head and abdomen to be submitted to NIH/NCI.
>However, I have some metal in there that was placed to stabilize a
>fracture of the right orbital

A review of my scans has ruled this out for me in terms of the trial.

>2) Hepatic Arterial Chemoembolization
>http://en.wikipedia.org/wiki/Neuroendocrine_tumor#Hepatic_artery-delivered_therapies
>which would be done at the Mallinkrodt Institute on the south campus at
>Barnes-Jewish.
>
>3) A liver transplant which I don't think my coverage will pay for.

I am flying out Sunday to check on option 4) a Phase 1 Trial of the
combination of Avastin [1] and Sprycel [2] being done at the NIH/NCI in
Bethesda. [3]

Other options that opened up include a trial being done at Siteman with
Rad001. [4]

>In other news, my apartment where I have lived for some 7 years has
>recently been determined to, by location (the building basement),
>violate St. Louis County's Building Codes. There is no remedy. It has
>been condemned and I have to move. The eviction order technically took
>effect March 16th. However, as this is not my fault and I have
>co-operated with the County, they are giving me leeway. I recently,
>with help from the county, obtained assistance from Catholic Charities
>of St. Louis and found an apartment. A deposit has been made and first
>month's rent paid as well. Current plans are to sign the lease on April
>14 and complete the move by the end of day on April 17th. I'll probably
>be offline from early Saturday until at least Monday. I'm hoping to get
>U-Verse at the new apartment. It seems I can get more TV channels, a
>better DVR than I currently have and the same Internet speed for less
>than what I pay Charter now (U-Verse is *not* available at my soon to be
>old location) - *if* U-Verse is available there (AT&T is supposed to be
>checking).
>
>[1] The pancreatic tumors having long been surgically removed - along
>with part of the pancreas (making me an instant diabetic), the spleen
>and the gall bladder.
>
>[2] http://en.wikipedia.org/wiki/Sunitinib
>http://en.wikipedia.org/wiki/Sunitinib#Other_solid_tumors

[1] http://en.wikipedia.org/wiki/Bevacizumab

[2] http://en.wikipedia.org/wiki/Dasatinib

[3]
http://bethesdatrials.cancer.gov/clinical-research/faq.aspx?ProtocolID=NCI-09-C-0019

[4] http://en.wikipedia.org/wiki/Everolimus
--
"So we cheated and we lied and we tested
And we never failed to fail it was the easiest thing to do"
- Stills, Curtis & Curtis